Myristoleate is an ester of fatty acid. Fatty acids are the individual
components of oils in the same way that amino acids are the building blocks
of proteins. Polyunsaturated fatty acids, such as linotenic acid and linolelic
acid, are crucial to life and are called essential fatty acids (EFAs).
Research shows that cetyl myristoleate appears to have the same beneficial
characteristics as the EFAs, however, it is stronger and the benefits are
are essential to normal cell structure, physiological processes, body function,
and function as components to nerve cells and cell membranes. EFAs are
depleted in chronic inflammatory diseases and their deficiency are associated
with many autoimmune diseases. EFAs when used over an extended period of
time have been shown to decrease pain, inflammation, and motion limitations
of arthritis. Cetyl myristoleate offers the same benefits in about a month
instead of extended periods of time..., which may be years.
we take a fatty acid, myristoleic acid, and combine it with a long-chain
alcohol molecule, cetyl alcohol, we have created an ester of this fatty
acid called cetyl myristoleate. Both of these molecules occur in nature.
Cetyl alcohol was first derived from the oil of the sperm whale, but now
is obtained from palmitic acid (a saturated fatty acid) found in coconut
and palm oils. Myristoleic acid is found in the oil glands of beavers,
the oil of the sperm whale again, in certain vegetables and nuts. Both
of these products were used in the cosmetic industry because of their ability
to act as lubricants. One of the mechanisms of cetyl myristoleate is as
a super lubricant (surfactant), a kind of WD-40 for the joints. A surfactant
not only has a dissolving or thinning action, it also makes other products
easier to absorb.
the treatment for arthritis, how can one product address all of the causes
of this complex disease?
myristoleate seems to function in three very different capacities.
as mentioned above, it serves as a surfactant and not only lubricates the
involved joints, but also lubricates the entire body, making muscles glide
more smoothly over other muscles, bursas, and bones and at the same time
softens these tissues making them more pliable. Secondly, it functions
as an immune system modulator. This is the reason it has been found to
be so effective in treating auto-immune diseases such as rheumatoid arthritis,
systemic lupus erythematosus, and multiple sclerosis. Thirdly, it functions
like a fatty acid in that it mediates inflammatory processes. When cooled,
cetyl myristoleate is a waxy substance and, at room temperature, has a
Was Cetyl Myristoleate Discovered?
myristoleate was discovered and isolated by one person, working alone,
on a quest to find a cure for arthritis. Harry W. Diehl, while employed
by the National Institutes of Arthritis, Metabolism, and Digestive Diseases,
specialized in sugar chemistry. He used his chemical knowledge and research
instincts to great advantage, identifying and characterizing over 500 compounds,
several of which were patented by the National Institutes of Health (NIH).
interest in discovering a way to help victims of arthritis began over 40
years ago when his friend and neighbor, a carpenter, developed severe rheumatoid
arthritis. His condition deteriorated over time until he became disabled.
The neighbor had a family to support, but his arthritis made that impossible.
Diehl is a deeply religious man whose feelings overwhelmed him as his friend's
condition worsened. Harry thought, "Here I am at the National Institutes
of Health, and I have never seen anything that was good for curing arthritis."
decided to establish a laboratory in his home and embark on a search for
something to relieve the pain and disability of his neighbor and the millions
of people who suffer from arthritis. Unfortunately, he was too late to
help the neighbor, but Diehl's research did lead to the discovery of cetyl
myristoleate, which may someday be hailed as one of the significant nutritional
discoveries of the 20th century.
a researcher, Diehl knew that finding a cure for arthritis first meant
inducing the disease experimentally in research animals. He started with
mice, and quickly realized that he was unable to induce arthritis in them.
Diehl said he tried every way he could to give those mice arthritis, but
they just would not get it. Then he contacted a researcher in California
who wrote back to him,
you or anyone else can give mice arthritis, I want to know about it, because
mice are 100% immune to arthritis."
that moment, Diehl's research instincts told him that what he wanted was
already somewhere in those mice. It was a long, tedious job, working on
his own in his spare time, but Diehl finally found the factor --cetyl myristoleate--
that protected mice from arthritis.
didn't come on a silver platter to me, but after years of chemical sleuthing
and just old fashioned chemical cooking, I found it!"
thin layer chromatography of methylene chloride extract from macerated
mice, Diehl noticed a mysterious compound, which was subsequently identified
as cetyl myristoleate. As Diehl was to prove, cetyl myristoleate circulates
in the blood of mice and makes them immune to arthritis.
myristoleate is now known to be found in sperm whale oil and a small gland
in the beaver. At this time no other sources in nature are known to contain
cetyl myristoleate. While the first amount of cetyl myristoleate for experimentation
was extracted from mice, Diehl quickly developed a method for making cetyl
myristoleate in the lab by esterification of myristoleic acid.
is the Chemical Make Up of Cetyl Myristoleate? A New Compound?
myristoleate, an oil, is the hexadecyl ester of the unsaturated fatty acid
cis-9-tetradecenoic acid. The common name for the acid is myristoleic acid.
Myristoleic acid is found commonly in fish oils, whale oils, dairy butter,
and kombo butter. The chemical formula for cetyl myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3.
Cetyl myristoleate was unrecorded in chemical literature until Diehl's
discovery was reported. The current Merck Index of Chemicals does not list
cetyl myristoleate. A search of Chemical Abstracts lists Diehl's method
of extracting cetyl myristoleate from mice but contains no reference to
cetyl myristoleate prior to his 1977 patent.
Did Harry Diehl Test CMO?
test his theory that mice are immune to arthritis because of cetyl myristoleate,
Diehl began to experiment on laboratory rats. This research was reported
in an article written in conjunction with one of his colleagues at NIH
in the Journal of Pharmaceutical Sciences. In summary, this paper reports
that ten normal mice were injected in the tail with Freund's Adjuvant (heat-killed
desiccated Mycobacterium butyricum) to which rats and certain other rodents
are susceptible. In a period of 10-20 days, no swelling was detected as
determined by comparison of the measurements of paws at the time of injection.
one group of rats was injected with cetyl myristoleate, and 48 hours later,
they were given Freund's adjuvant. Another control group of rats received
Freund's adjuvant only. Both groups of rats were observed for a total
of 58 days with respect to weight change, hind and front leg swelling,
and general well being. All rats receiving only Freund's adjuvant developed
severe swelling of the front and hind legs, lagged in weight gain, and
was lethargic and morbid. Those receiving cetyl myristoleate before receiving
Freund's adjuvant grew an average of 5.7 times as much as the control group
and had little if any evidence of swelling or other symptoms of polyarthritis.
authors concluded that it was apparent that cetyl myristoleate gave virtually
complete protection against adjuvant-induced arthritis in rats.
Harry Diehl Patent CMO?
patented his discovery in 1977, receiving a use patent for rheumatoid arthritis.
Diehl had made a major nutritional discovery. He then sought pharmaceutical
companies to conduct human trials with cetyl myristoleate, but none were
interested in his discovery. Perhaps the lack of interest was because cetyl
myristoleate was a natural substance and could not be granted a product
patent, or maybe because drug companies know they will have to run through
25,000 to 35,000 substances before they find one that makes the market.
Diehl had made a major nutritional discovery, and no one was interested!
Being a scientist, not a marketing expert, Diehl let his discovery lay
dormant for about 15 years.
Myristoleate Cures Diehl's Arthritis
Diehl got older, he began to experience some osteoarthritis in his hand,
his knees, and his heels. His family physician tried the usual regimen
of coritsone and non-steroidal anti-inflammatory drugs without much effect
on the course of the disease. Finally his physician told Harry he could
not have any more cortisone. "So," Diehl said "I thought about my discovery,
and I decided to make a batch and use it on myself." He did, and successfully
cured himself of his osteoarthritis.
of his family members and friends became aware of the relief Diehl found
from his discovery, and they wanted to try it too. Time after time, people
with both rheumatoid arthritis and osteoarthritis received astounding relief
with cetyl myristoleate. Before long, family members and friends grew into
customers, and cetyl myristoleate appeared on the market as a dietary supplement.
Again for Osteoarthritis
more people tried Harry's cetyl myristoleate and either eliminated their
arthritis or received substantial long-term relief, they told others and
demand for the product grew. At this point Harry decided to file for a
patent for using CM for osteoarthritis. He received the patent in 1996.
The patent was assigned to EHP Products, the company owned and led by his
daughter, Elaine Diehl Parrish. EHP Products has established a licensing
program under the patent and only companies licensed under this patent
will be authorized to use the trademark name MyristinTM. This name is an
assurance that the product is the true cetyl myristoleate discovered by
Harry Diehl, is pure, and of the highest quality available. (Vaughn Marketing
is a company licensed under this patent.)
of his family members and friends became aware of the relief Diehl found
from his discovery, and they wanted to try it too. Time after time,
people with both rheumatoid arthritis and osteoarthritis received astounding
relief with cetyl myristoleate. Before long, family members and friends
grew into customers, and cetyl myristoleate appeared on the market as a
Happens When Humans Take CMO?
osteoarthritis and rheumatoid arthritis sufferers report striking improvements
with cetyl myristoleate. Numerous private correspondence describe
decreased stiffness and pain and increased flexibility and range of motion
with cetyl myristoleate. Swelling and redness is reduced in rheumatoid
describe other health benefits, including positive effects of cetyl myristoleate
on emphysema, hepatitis, hypertension, diabetes, eczema, psoriasis, colds,
allergies, low back pain, headaches and more. These reported improvements
in general health status are not surprising since each of these conditions
could be associated with deficiency in the balance of Essential Fatty Acids.
writer, Douglas Hunt, M.D., in his book Boom You're Well With Cetyl Myristoleate
calls cetyl myristoleate "A New Natural Anti-Aging Disease Fighter".
everything else, cetyl myristoleate does not work 100% of the time. Failure
to work can be associated with failure to follow the dietary recommendations;
failure to use lipase in conjunction with each capsule of cetyl myristoleate;
failure to take sufficient amounts of cetyl myristoleate; failure of the
liver to uptake and respond to the cetyl myristoleate; and misdiagnosis
in which the condition is not really an arthritis-type condition.
Much & How Long Does One Have To Take CMO To Feel Its Effects?
- 12 grams per Mr. Diehl. Some will usually respond in the first 7 - 21
myristoleate is taken in a one-month course. A total dose of 12 - 15 grams
appears to be indicated. This is usually enough for most people, but for
osteoarthritic sufferers, the dose appears to be related to the number
of areas in which cartilage has worn away. For example, a patient with
osteoarthritis of the knees could expect 10 to 15 grams to sufficient in
most cases, while a patient with osteoarthritis of 5 or 6 spinal discs,
both hips and both knees may require an additional 5 to 10 grams, or even
a full second course.
CMO Have Side Effects?
negative ones have been observed or noted.
than having negative side effects, CMO appears to have many positive ones!
According to many researchers and scientists, doctors using CMO in their
practices, along with writers of articles and authors of books on Cetyl
Myristoleate, CMO works on many other autoimmune diseases and even has
the hundreds of people who have taken cetyl myristoleate there have been
no confirmed reports of adverse side effects. In common with fish oils,
it may produce some mild burping in some people which passes within an
hour. There have been no reported interactions with other medications or
studies have been performed on cetyl myristoleate and the lack of toxicity
is evident. Test results deemed cetyl myristoleate a non-toxic material
in accordance with Federal regulations. Mega-doses were given to test animals
with no ill effects. Necropsy of test animals showed no ill effects on
the internal organs. The LD50 of cetyl myristoleate was not established,
but it can be presumed to far exceed 10 grams per kilogram of body weight.
teratogenicity of cetyl myristoleate is probably the same as for EFA's,
as a safety matter, cetyl myristoleate should not be used by pregnant or
lactating women until studies of cetyl myristoleate's effects on fetuses
and infants have been done. As with any substance being added to the diet
of anyone with asthma or a history of severe allergies, the direct supervision
of a health care professional is recommended.